United States securities and exchange commission logo

                          September 1, 2020

       David L. Lucchino
       President and Chief Executive Officer
       Frequency Therapeutics, Inc.
       19 Presidential Way, 2nd Floor
       Woburn, MA 01801

                                                        Re: Frequency
Therapeutics, Inc.
Statement on Form S-1
                                                            Filed August 28,
                                                            File No. 333-248474

       Dear Mr. Lucchino:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tim
Buchmiller at (202) 551-3635 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              John Chory, Esq.