United States securities and exchange commission logo November 19, 2020 David L. Lucchino President and Chief Executive Officer Frequency Therapeutics, Inc. 19 Presidential Way, 2nd Floor Woburn, MA 01801 Re: Frequency Therapeutics, Inc. Registration Statement on Form S-3 Filed November 16, 2020 File No. 333-250099 Dear Mr. Lucchino: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Tim Buchmiller at (202) 551-3635 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Nathan Ajiashvili, Esq.